{"product_id":"tbk1-polyclonal-antibody-bt-ap08858","title":"TBK1 Polyclonal Antibody - BT-AP08858","description":"\u003cp\u003eTBK1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP08858-20, BT-AP08858-50, BT-AP08858-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The TANK binding kinase 1 encoded by TBK1 is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: TBK1\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: TBK1 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 83642\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9UHD2; Mouse: Q9WUN2\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: TBK1; NAK; Serine\/threonine-protein kinase TBK1; NF-kappa-B-activating kinase; T2K; TANK-binding kinase 1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 29110; Mouse: 56480\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239937204403,"sku":"BT-AP08858-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239937237171,"sku":"BT-AP08858-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239937269939,"sku":"BT-AP08858-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_536a9a26-ba66-47eb-947f-179d9ecbadd4.png?v=1769401167","url":"https:\/\/afsbio.com\/products\/tbk1-polyclonal-antibody-bt-ap08858","provider":"AFSBio Inc.","version":"1.0","type":"link"}