{"product_id":"tca-rabbit-polyclonal-antibody-bt-ap12990","title":"TCA Rabbit Polyclonal Antibody - BT-AP12990","description":"\u003cp\u003eTCA Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP12990-20, BT-AP12990-50, BT-AP12990-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell| the T cell receptor loci are rearranged and expressed in the order delta| gamma| beta| and alpha. If both delta and gamma rearrangements produce functional chains| the cell expresses delta and gamma. If not| the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable)| J (joining)| and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus| between the alpha V and J segments. During T cell development| the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains| the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity| resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV\/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: others\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: TRAC\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: TCA\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 15620\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P01848; Mouse: P01849\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: TCA\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45238922805427,"sku":"BT-AP12990-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45238922838195,"sku":"BT-AP12990-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238922870963,"sku":"BT-AP12990-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_75a3b6f8-2a15-4618-ab95-ccfe9b8b7e24.png?v=1769386736","url":"https:\/\/afsbio.com\/products\/tca-rabbit-polyclonal-antibody-bt-ap12990","provider":"AFSBio Inc.","version":"1.0","type":"link"}