{"product_id":"tcam2-rabbit-polyclonal-antibody-es11113","title":"TCAM2 Rabbit Polyclonal Antibody - ES11113","description":"\u003cp\u003eTCAM2 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES11113-50, ES11113-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: TIRP is a Toll\/interleukin-1 receptor (IL1R, MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4, MIM 603030).[supplied by OMIM, Apr 2004],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from part region of human protein\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: TCAM2\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: TCAM2 Polyclonal Antibody detects endogenous levels of protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1),\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 25kD\u003c\/p\u003e\n\n\u003cp\u003eFields: NF-kappa B signaling pathway, Necroptosis, Toll-like receptor signaling pathway, Pertussis, Hepatitis B, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis\u003c\/p\u003e\n\n\u003cp\u003eFunction: Domain: The TIR domain mediates the interaction with TRAF6\u003cbr\u003e\nFunction: Functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1\u003cbr\u003e\nPTM: Myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling\u003cbr\u003e\nPTM: Phosphorylated by PKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation\u003cbr\u003e\nSimilarity: Belongs to the EMP24\/GP25L family\u003cbr\u003e\nSimilarity: Contains 1 GOLD domain\u003cbr\u003e\nSimilarity: Contains 1 TIR domain\u003cbr\u003e\nSubcellular Location: Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: [Isoform 1]: Cytoplasm Golgi apparatus Cell membrane Endoplasmic reticulum Early endosome membrane Late endosome membrane Cell projection, phagocytic cup Localized to the plasma membrane as a result of myristoylation Phosphorylation on Ser-16 leads to its depletion from the membrane Upon LPS stimulation colcoalizes with isoform 2 in late endosomes, [Isoform 2]: Endoplasmic reticulum Early endosome membrane Late endosome membrane Translocates to late endosomes upon LPS stimulation where it colcoalizes with isoform 1\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: TICAM2 TIRAP3 TIRP TRAM\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: TIR domain-containing adapter molecule 2 (TICAM-2) (Putative NF-kappa-B-activating protein 502) (TRIF-related adapter molecule) (Toll-like receptor adaptor protein 3) (Toll\/interleukin-1 receptor doma\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q8BJQ4\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314383343795,"sku":"ES11113-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314383376563,"sku":"ES11113-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/tcam2-rabbit-polyclonal-antibody-es11113","provider":"AFSBio Inc.","version":"1.0","type":"link"}