{"product_id":"tcf-3-rabbit-pab-es3573","title":"TCF-3 rabbit pAb - ES3573","description":"\u003cp\u003eTCF-3 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES3573-50, ES3573-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t (1; 19), with PBX1), childhood leukemia (t (19; 19), with TFPT) and acute leukemia (t (12; 19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have bee\u003c\/p\u003e\n\n\u003cp\u003eAlternate Name: TCF3; BHLHB21; E2A; ITF1; Transcription factor E2-alpha; Class B basic helix-loop-helix protein 21; bHLHb21; Immunoglobulin enhancer-binding factor E12\/E47; Immunoglobulin transcription factor 1; Kappa-E2-binding factor; Transcription facto\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human TCF3. AA range:571-620\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 68kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 6929\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P15923\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202142167219,"sku":"ES3573-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202142199987,"sku":"ES3573-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_957d36e4-9073-4070-8206-fb0efc9006d7.png?v=1767122891","url":"https:\/\/afsbio.com\/products\/tcf-3-rabbit-pab-es3573","provider":"AFSBio Inc.","version":"1.0","type":"link"}