{"product_id":"tcf3-polyclonal-antibody-bs91323","title":"TCF3 Polyclonal Antibody-BS91323","description":"\u003cp\u003eTCF3 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS91323-50, BS91323-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P15923(Human)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, FC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:1,000\u003cbr\u003e\nFC:1:50-1:100\u003c\/p\u003e\n\n\u003cp\u003eBackground: Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development include Myo D, myogenin, Myf-5 and Myf-6 (also designated MRF-4 or herculin). Myo D transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. Myo D-E heterodimers bind avidly to consensus (CANNTG) E box target sites that are functionally important elements in the upstream regulatory sequences of many muscle-specific terminal differentiation genes. Both homo- and heterooligomers of these proteins are able to distinguish very closely related E box proteins and are believed to play important roles in lineage specific gene expression.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: ProA affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Flow cytometric analysis of 293 cells with TCF3 antibody at 1\/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as theSecondary antibody.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 67 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: TCF3 polyclonal antibody detects endogenous levels of TCF3 protein.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: bHLHb21, TCF-3, TCF3, AGM8, bHLHb21, Class B basic helix-loop-helix protein 21, E12, E2A, E2A immunoglobulin enhancer binding factors E12\/E47, E47, Helix loop helix protein HE47, Immunoglobulin enhancer-binding factor E12\/E47, Immunoglobulin transcription factor 1, ITF1, Kappa-E2-binding factor, MGC129647, MGC129648, Negative vitamin D response element binding protein, NOL1-TCF3 fusion, TCF-3, Tcf3, TFE2, transcription factor 3 (E2A immunoglobulin enhancer binding factors E12\/E47), Transcription factor 3, transcription factor 3 variant 3, Transcription factor E2-alpha, Transcription factor ITF-1, VDIR, VDR interacting repressor, vitamin D receptor-interacting repressor,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: recombinant protein\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42939209285811,"sku":"BS91323-50","price":415.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42939209318579,"sku":"BS91323-100","price":640.78,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_6e480a67-f6f0-4a4e-84d9-ffd90a0827e7.jpg?v=1704545102","url":"https:\/\/afsbio.com\/products\/tcf3-polyclonal-antibody-bs91323","provider":"AFSBio Inc.","version":"1.0","type":"link"}