{"product_id":"tcl1a-monoclonal-antibody-bt-mca3865","title":"TCL1A Monoclonal Antibody - BT-MCA3865","description":"\u003cp\u003eTCL1A Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA3865-50, BT-MCA3865-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-\/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling, Cancer\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: TCL1A\u003c\/p\u003e\n\n\u003cp\u003eApplications: FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 2E3A5\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: TCL1A\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human TCL1A (AA: 10-104) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 13.5kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P56279\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: TCL1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 8115\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238558851251,"sku":"BT-MCA3865-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238558884019,"sku":"BT-MCA3865-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_dd620896-cf76-43d5-964c-eab37a62604b.png?v=1769382556","url":"https:\/\/afsbio.com\/products\/tcl1a-monoclonal-antibody-bt-mca3865","provider":"AFSBio Inc.","version":"1.0","type":"link"}