{"product_id":"tdg-polyclonal-antibody-e-ab-92674","title":"TDG Polyclonal Antibody - E-AB-92674","description":"\u003cp\u003eTDG Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-92674-60, E-AB-92674-120, E-AB-92674-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: TDG\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: TDG; hTDG\u003c\/p\u003e\n\n \n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q13569\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the TDG\/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G\/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C\/T and T\/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human TDG\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 46kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 50KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43145956262067,"sku":"E-AB-92674-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43145956294835,"sku":"E-AB-92674-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43145956327603,"sku":"E-AB-92674-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_bb1f980b-11d6-4f9c-b8f0-101158f440ca.png?v=1710288800","url":"https:\/\/afsbio.com\/products\/tdg-polyclonal-antibody-e-ab-92674","provider":"AFSBio Inc.","version":"1.0","type":"link"}