{"product_id":"tensin-1-phospho-tyr1326-rabbit-polyclonal-antibody-es1531","title":"Tensin-1 (phospho Tyr1326) Rabbit Polyclonal Antibody - ES1531","description":"\u003cp\u003eTensin-1 (phospho Tyr1326) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES1531-50, ES1531-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: TNS1, TNS, Tensin-1\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized phospho-peptide around the phosphorylation site of human Tensin-1 (phospho Tyr1326)\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: Tensin-1\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Phospho-Tensin-1 (Y1326) Polyclonal Antibody detects endogenous levels of Tensin-1 protein only when phosphorylated at Y1326.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Ubiquitous,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 185kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton\u003cbr\u003e\nPTM: Rapidly cleaved by calpain II\u003cbr\u003e\nPTM: Tyrosine phosphorylated\u003cbr\u003e\nSimilarity: Contains 1 C2 tensin-type domain\u003cbr\u003e\nSimilarity: Contains 1 phosphatase tensin-type domain\u003cbr\u003e\nSimilarity: Contains 1 SH2 domain\u003cbr\u003e\nSubunit: Binds to actin filaments and interacts with phosphotyrosine-containing proteins. Interacts with STARD8\u003cbr\u003e\nTissue Specificity: Ubiquitous\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Cell surface Cell junction, focal adhesion Cytoplasm, cytoskeleton Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: TNS1\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Tensin-1\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315243307187,"sku":"ES1531-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315243339955,"sku":"ES1531-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/tensin-1-phospho-tyr1326-rabbit-polyclonal-antibody-es1531","provider":"AFSBio Inc.","version":"1.0","type":"link"}