{"product_id":"tfdp1-polyclonal-antibody-bs7264","title":"TFDP1 Polyclonal Antibody - BS7264","description":"\u003cp\u003eTFDP1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS7264-50, BS7264-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The human retinoblastoma gene product appears to play an important role in the negative egμlation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus-encoded proteins. Of all the Rb associations described to date, the identification of a complex between Rb and the transcription factor E2F most directly implicates Rb in regμlation of cell proliferation. E2F was originally identified through its role in transcriptional activation of the adenovirus E2 promoter. Sequences homologous to the E2F binding site have been found upstream of a number of genes that encode proteins with putative functions in the G1 and S phases of the cell cycle. E2F-1 forms heterodimers with a second protein, designated DP-1, forming an “active” E2F transcriptional regμlatory complex. Additional members of the E2F family include E2F-2, E2F-3, E2F-4, E2F-5 and DP-2.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: DP - 1 Transcription Factor, E2F dimerization partner 1, DRTF1-polypeptide 1, DRTF1, DP1, 7027, TFDP1, 189902, Q14186, DP1, DRTF1, Dp-1,\u003c\/p\u003e \n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fμll length Human TFDP1.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB\t1:500 - 1:2000\u003cbr\u003e\nIHC\t1:50 - 1:200\u003cbr\u003e\nIF\t1:50 - 1:200\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: TFDP1 polyclonal antibody detects endogenous levels of TFDP1 protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: Refer to figures\u003c\/p\u003e\n\n\u003cp\u003ePathway: Cell Cycle Control G1 S Checkpoint,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: Q14186\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946381861043,"sku":"BS7264-50","price":349.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946381893811,"sku":"BS7264-100","price":582.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/tfdp1-polyclonal-antibody-bs7264","provider":"AFSBio Inc.","version":"1.0","type":"link"}