{"product_id":"tgf-beta-2-monoclonal-antibody-mb67044","title":"TGF beta 2 Monoclonal Antibody - MB67044","description":"\u003cp\u003eTGF beta 2 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB67044-50, MB67044-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Transforming growth factor-β (TGF-β) superfamily members are critical regμlators of cell proliferation and differentiation, developmental patterning and morphogenesis, and disease pathogenesis . TGF-β elicits signaling through three cell surface receptors: type I (RI), type II (RII), and type III (RIII). Type I and type II receptors are serine\/threonine kinases that form a heteromeric complex. In response to ligand binding, the type II receptors form a stable complex with the type I receptors allowing phosphorylation and activation of type I receptor kinases . The type III receptor, also known as betaglycan, is a transmembrane proteoglycan with a large extracellμlar domain that binds TGF-β with high affinity but lacks a cytoplasmic signaling domain . Expression of the type III receptor can regμlate TGF-β signaling through presentation of the ligand to the signaling complex. The only known direct TGF-β signaling effectors are the Smad family proteins, which transduce signals from the cell surface directly to the nucleus to regμlate target gene transcription .Three isoforms of TGF-β, designated TGF-β1, TGF-β2 and TGF-β3, are encoded by distinct genes and are expressed in a tissue specific manner . Each isoform is synthesized as a larger precursor protein containing a propeptide region that is removed prior to secretion. Mature TGF-β contains two polypeptides linked by disμlfide bonds to form a protein of approximately 25 kDa.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF\/ICC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Transforming growth factor beta-2, TGF-beta-2, BSC-1 cell growth inhibitor, Cetermin, Glioblastoma-derived T-cell suppressor factor, G-TSF, Polyergin\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human TGF beta 2. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB (1\/500 - 1\/1000), IHC (1\/50 - 1\/200), IF\/ICC (1\/10 - 1\/50)\u003c\/p\u003e\n\n\u003cp\u003ePurification: This antibody is purified through a protein G column.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of TGF beta 2 protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 48 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Signaling Pathways Activating p38 MAP Kinase, Wntβ catenin signaling.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P61812\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946430095539,"sku":"MB67044-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946430128307,"sku":"MB67044-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/tgf-beta-2-monoclonal-antibody-mb67044","provider":"AFSBio Inc.","version":"1.0","type":"link"}