{"product_id":"tigar-polyclonal-antibody-bt-ap14968","title":"TIGAR Polyclonal Antibody - BT-AP14968","description":"\u003cp\u003eTIGAR Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP14968-20, BT-AP14968-50, BT-AP14968-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cell biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: TIGAR\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Fructose-2,6-bisphosphatase TIGAR\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9NQ88; Mouse: Q8BZA9\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Fructose-2,6-bisphosphatase TIGAR;EC 3.1.3.46;TP53-induced glycolysis and apoptosis regulator\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 57103\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239388831923,"sku":"BT-AP14968-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239388864691,"sku":"BT-AP14968-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239388897459,"sku":"BT-AP14968-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_51ab4d9b-4108-488d-8586-551a779dafdd.png?v=1769393842","url":"https:\/\/afsbio.com\/products\/tigar-polyclonal-antibody-bt-ap14968","provider":"AFSBio Inc.","version":"1.0","type":"link"}