{"product_id":"timp-2-polyclonal-antibody-bt-ap09035","title":"TIMP-2 Polyclonal Antibody - BT-AP09035","description":"\u003cp\u003eTIMP-2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP09035-20, BT-AP09035-50, BT-AP09035-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: TIMP2 is a member of the TIMP gene family. Metalloproteinase inhibitor 2 encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the Metalloproteinase inhibitor 2 has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cardiovascular\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: TIMP2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: TIMP-2 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 24399\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P16035; Mouse: P25785; Rat: P30121\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: TIMP2; Metalloproteinase inhibitor 2; CSC-21K; Tissue inhibitor of metalloproteinases 2; TIMP-2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 7077; Rat: 29543\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239950114995,"sku":"BT-AP09035-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239950147763,"sku":"BT-AP09035-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239950180531,"sku":"BT-AP09035-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_05f1ec67-6e47-465d-b393-42232af9aa88.png?v=1769401325","url":"https:\/\/afsbio.com\/products\/timp-2-polyclonal-antibody-bt-ap09035","provider":"AFSBio Inc.","version":"1.0","type":"link"}