{"product_id":"timp1-polyclonal-antibody-e-ab-66160","title":"TIMP1 Polyclonal Antibody - E-AB-66160","description":"\u003cp\u003eTIMP1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-66160-60, E-AB-66160-120, E-AB-66160-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: TIMP1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: TIMP1; CLGI; EPA; EPO; HCI; TIMP; TIMP-1\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer,Cell Biology,Cardiovascular,Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IF\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P01033\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human TIMP1\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IF 1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 23kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 26KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146408034483,"sku":"E-AB-66160-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146408067251,"sku":"E-AB-66160-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146408100019,"sku":"E-AB-66160-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_007bed0f-ad49-40c8-9498-9c983847ebaf.png?v=1710295024","url":"https:\/\/afsbio.com\/products\/timp1-polyclonal-antibody-e-ab-66160","provider":"AFSBio Inc.","version":"1.0","type":"link"}