{"product_id":"tin2-polyclonal-antibody-bt-ap09039","title":"TIN2 Polyclonal Antibody - BT-AP09039","description":"\u003cp\u003eTIN2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP09039-20, BT-AP09039-50, BT-AP09039-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: TINF2 encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The TERF1 interacting nuclear factor 2 encoded by TINF2 is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: TINF2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: TIN2 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 50023\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9BSI4; Mouse: Q9QXG9\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: TINF2; TIN2; TERF1-interacting nuclear factor 2; TRF1-interacting nuclear protein 2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 26277\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239950639283,"sku":"BT-AP09039-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239950672051,"sku":"BT-AP09039-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239950704819,"sku":"BT-AP09039-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_66abf60c-3a7f-4cb6-b02f-c195f71950e2.png?v=1769401333","url":"https:\/\/afsbio.com\/products\/tin2-polyclonal-antibody-bt-ap09039","provider":"AFSBio Inc.","version":"1.0","type":"link"}