{"product_id":"tisotumab-elisa-kit-db058018","title":"Tisotumab ELISA Kit - DB058018","description":"\u003cp\u003eTisotumab ELISA Kit\u003c\/p\u003e\n\n\u003cp\u003eSize: 96T\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: DB058018-96\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eStability and Storage: The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition.\u003c\/p\u003e\n\n\u003cp\u003eDetection Method: Colorimetric\u003c\/p\u003e\n\n\u003cp\u003eSample Type: Plasma, Serum\u003c\/p\u003e\n\n\u003cp\u003eAssay Type: Quantitative\u003c\/p\u003e\n\n\u003cp\u003eSensitivity: 0.156 μg\/ml\u003c\/p\u003e\n\n\u003cp\u003eRange: 0.31-5 μg\/mL\u003c\/p\u003e\n\n\u003cp\u003eRecovery: 80-120%\u003c\/p\u003e\n\n\u003cp\u003eBackground: Tisotumab vedotin, also known as HuMax-TF, HuMax®-TF-ADC or TF-011-MMAE, is an antibody-drug conjugate (ADC) targeted to tissue factor (TF), a protein involved in tumor signaling and angiogenesis. Tisotumab vedotin includes an antibody targeting TF conjugated with monomethyl auristatin E (MMAE) via a cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker. Based on its high expression on many solid tumors (including ovarian, prostate, bladder, esophageal, endometrial and lung) and its rapid internalization, TF is considered a suitable target for antibody-drug conjugates. In pre-clinical trials tisotumab vedotin has shown strong ability to bind to TF and inhibit tumor growth. Genmab and Seattle Genetics are jointly developing tisotumab vedotin. In a Phase IIa study, preliminary data demonstrated a manageable safety profile and encouraging efficacy (ORR 37%) in relapsed, recurrent or metastatic cervical cancer.\u003c\/p\u003e\n\n\u003cp\u003eShipping: 2-8 ℃\u003c\/p\u003e\n\n\u003cp\u003eFor Research Use Only.\u003c\/p\u003e","brand":"abinScience","offers":[{"title":"Default Title","offer_id":45353676701875,"sku":"DB058018-96","price":1576.4,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/abinscience.png?v=1773676488","url":"https:\/\/afsbio.com\/products\/tisotumab-elisa-kit-db058018","provider":"AFSBio Inc.","version":"1.0","type":"link"}