{"product_id":"tle3-rabbit-polyclonal-antibody-es12682","title":"TLE3 Rabbit Polyclonal Antibody - ES12682","description":"\u003cp\u003eTLE3 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES12682-50, ES12682-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human TLE3 AA range: 257-307\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: TLE3\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of TLE3 at Human\/Mouse\/Rat\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.343% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Placenta and lung,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 85kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Wnt signaling pathway, Notch signaling pathway\u003c\/p\u003e\n\n\u003cp\u003eFunction: Alternative Products: Experimental confirmation may be lacking for some isoforms,Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES\u003cbr\u003e\nSimilarity: Belongs to the WD repeat Groucho\/TLE family\u003cbr\u003e\nSimilarity: Contains 7 WD repeats\u003cbr\u003e\nSubunit: Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1 and TCF7L2 (By similarity). Binds FOXA2\u003cbr\u003e\nTissue Specificity: Placenta and lung\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Nucleus\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: TLE3 KIAA1547\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: TLE3\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 21887\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q08122\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 84424\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q9JIT3\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314842226867,"sku":"ES12682-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314842259635,"sku":"ES12682-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/tle3-rabbit-polyclonal-antibody-es12682","provider":"AFSBio Inc.","version":"1.0","type":"link"}