{"product_id":"tmem173-polyclonal-antibody-bs91357","title":"TMEM173 Polyclonal Antibody-BS91357","description":"\u003cp\u003eTMEM173 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS91357-50, BS91357-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q86WV6(Human)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, FC, ICC\/IF\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:500-1:1,000\u003cbr\u003e\nFC:1:50-1:100\u003cbr\u003e\nICC:1:10-1:50\u003c\/p\u003e\n\n\u003cp\u003eBackground: Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: ProA affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: TMEM173 polyclonal antibody detects endogenous levels of TMEM173 protein.\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of TMEM173 on U937 (1) and 293 (2) cell lysate using anti-TMEM173 antibody at 1\/1,000 dilution., Flow cytometric analysis of THP-1 cells with TMEM173 antibody at 1\/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42892366348467,"sku":"BS91357-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42892366381235,"sku":"BS91357-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_6281b886-15a8-469a-8482-e43ac9c42ebf.jpg?v=1702483928","url":"https:\/\/afsbio.com\/products\/tmem173-polyclonal-antibody-bs91357","provider":"AFSBio Inc.","version":"1.0","type":"link"}