{"product_id":"tnf-alpha-monoclonal-antibody-bt-mca3611","title":"TNF-alpha Monoclonal Antibody - BT-MCA3611","description":"\u003cp\u003eTNF-alpha Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA3611-50, BT-MCA3611-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: TNF-alpha (tumor necrosis factor alpha) is an important cytokine produced by numerous cell types including neutrophils, activated lymphocytes, macrophages and NK cells. It plays a critical role in inflammatory responses and in apoptosis. TNF-alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF-alpha exists as a multimer of two, three, or five non covalently linked units, but shows a single 17 kDa band following SDS PAGE under non reducing conditions. Although it has little effect on many cultured normal human cells, TNF-alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF-alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF-alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Others\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: TNF-alpha\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 2A9B9\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: TNF-alpha\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant Human TNF-alpha (BioSource company, Cat.No. PHC3013)\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P01375\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: DIF, TNFA, TNFSF2, TNF-alpha\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 7124\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238368403635,"sku":"BT-MCA3611-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238368436403,"sku":"BT-MCA3611-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_57401721-91a5-4300-a826-f4009d16e579.png?v=1769379272","url":"https:\/\/afsbio.com\/products\/tnf-alpha-monoclonal-antibody-bt-mca3611","provider":"AFSBio Inc.","version":"1.0","type":"link"}