{"product_id":"tnfrsf13c-polyclonal-antibody-e-ab-90789","title":"TNFRSF13C Polyclonal Antibody - E-AB-90789","description":"\u003cp\u003eTNFRSF13C Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-90789-60, E-AB-90789-120, E-AB-90789-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: TNFRSF13C\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: TNFRSF13C; BAFF-R; BAFFR; BROMIX; CD268; CVID4; prolixin\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q96RJ3\u003c\/p\u003e\n\n\u003cp\u003eBackground: B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human TNFRSF13C\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 18kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 19kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146574659763,"sku":"E-AB-90789-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146574692531,"sku":"E-AB-90789-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146574725299,"sku":"E-AB-90789-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_e2c9b98c-c656-4209-ae17-65b04e4a70aa.png?v=1710297691","url":"https:\/\/afsbio.com\/products\/tnfrsf13c-polyclonal-antibody-e-ab-90789","provider":"AFSBio Inc.","version":"1.0","type":"link"}