{"product_id":"tnfsf14-polyclonal-antibody-bs65551","title":"TNFSF14 Polyclonal Antibody-BS65551","description":"TNFSF14 Polyclonal Antibody\n\nProduct: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\n\nSizes: 50µl, 100µl\n\nCatalogue Numbers: BS65551-50, BS65551-100\n\nSwiss-Prot: Q9QYH9\n\nHost: Rabbit\n\nTNFSF14 Polyclonal Antibody-BS65551\n\nStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\n\nReactivity: Mouse,\n\nApplications: WB,\n\nAll Applications: WB=1:500-2000 \nnot yet tested in other applications.\noptimal dilutions\/concentrations should be determined by the end user.\n\nBackground: LIGHT protein is a type II transmembrane protein and a tumor necrosis factor (TNF) ligand superfamily member (TNFSF14). LIGHT is expressed on activated T cells and immature dendritic cells and its receptors have been identified as lymphotoxin-Beta receptor (LTBetaR) and the herpesvirus entry mediator (HVEM), both of which lack the cytoplasmic sequence termed as \"death domain.\" LIGHT is first identified as HVEM ligand (HVEM-L) and a deterrent to herpesvirus infection according to its ability to compete with HSV glycoprotein D for HVEM binding. As a T cell-derived costimulatory ligand, TNFSF14 plays a crucial role in T cell activation and proliferation by LIGHT-LTBetaR interaction, and it is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. Additionally, recent studies also establish a direct role for LIGHT in NK activation\/expansion via LIGHT-HVEM interaction, and thus breaking T-cell tolerance at the tumor site. Accordingly, LIGHT is suggested to be involved in CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Although known as lymphotoxin-Gamma, LIGHT plays a minimal role in lymphoid tissue development in contrast with LT-Alpha and Beta. This protein was also demonstrated to inhibit TNF-Alpha-mediated but not Fas- or TRAIL-mediated apoptosis of human primary hepatocytes.\n\nPurification and Purity: affinity purified by Protein A\n\nSpecificity: TNFSF14 polyclonal Antibody detects endogenous levels of TNFSF14 protein.\n\nBioworld Molecular Weight: ~26kDa\n\nNote: For research use only, not for use in diagnostic procedure.\n\nExtra Notes: Anti-TNFSF14 at 1\/1000 dilution, Anti- TNFSF14 at 1\/1000 dilution\n\nAlternative Name: CD 258; CD258; CD258 antigen; Delta transmembrane LIGHT; Herpes virus entry mediator ligand; Herpesvirus entry mediator A; Herpesvirus entry mediator ligand; herpesvirus entry mediator-ligand; HVEM L; HVEM-L; HVEML; Ligand for herpesvirus entry mediator; LIGHT; LTg; soluble form; TNF14; TNF14_HUMAN; TNFSF 14; TNFSF14 protein; TR 2; TR2; Tumor necrosis factor (ligand) superfamily, member 14; Tumor necrosis factor ligand superfamily member 14; Tumor necrosis factor ligand superfamily, member 14; Tumor necrosis factor receptor like 2; tumor necrosis factor receptor-like 2; Tumor necrosis factor superfamily member 14; Tumor necrosis factor superfamily member LIGHT.\n\nImmunogen: KLH conjugated synthetic peptide derived from mouse TNFSF14:59-130\/239 \u003cextracellular\u003e\n\nModification: Unmodified\n\nConjugate: Unconjugated\u003c\/extracellular\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42962743460019,"sku":"BS65551-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42962743492787,"sku":"BS65551-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_583402a2-6268-412c-83ab-d29d7f499e50.jpg?v=1705318688","url":"https:\/\/afsbio.com\/products\/tnfsf14-polyclonal-antibody-bs65551","provider":"AFSBio Inc.","version":"1.0","type":"link"}