{"product_id":"tnk1-phospho-tyr277-rabbit-polyclonal-antibody-bt-ap13110","title":"TNK1 (Phospho-Tyr277) Rabbit Polyclonal Antibody - BT-AP13110","description":"\u003cp\u003eTNK1 (Phospho-Tyr277) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP13110-20, BT-AP13110-50, BT-AP13110-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways| mediating cellular proliferation| survival| and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues| thus may function in signaling pathways utilized broadly during fetal development| and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway| and knockout mice have been shown to develop spontaneous tumors| suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Signal transduction; Cancer; Cell biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: TNK1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: TNK1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q13470; Mouse: Q99ML2\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: TNK1;Tyr277; Non-receptor tyrosine-protein kinase TNK1; EC 2.7.10.2; CD38 negative kinase 1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 8711; Mouse: 83813\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239027761331,"sku":"BT-AP13110-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239027794099,"sku":"BT-AP13110-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239027826867,"sku":"BT-AP13110-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_b8b128c6-51ef-4e59-ab11-d423314d23b9.png?v=1769388106","url":"https:\/\/afsbio.com\/products\/tnk1-phospho-tyr277-rabbit-polyclonal-antibody-bt-ap13110","provider":"AFSBio Inc.","version":"1.0","type":"link"}