{"product_id":"tnni2-monoclonal-antibody-bt-mca4539","title":"TNNI2 Monoclonal Antibody - BT-MCA4539","description":"\u003cp\u003eTNNI2 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4539-50, BT-MCA4539-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: TNNI2\u003c\/p\u003e\n\n\u003cp\u003eApplications: ICC, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 2F12G2\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: TNNI2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human TNNI2 expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 21kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P48788\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: DA2B, FSSV, fsTnI, AMCD2B\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 7136\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238580641971,"sku":"BT-MCA4539-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238580674739,"sku":"BT-MCA4539-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_21b3e329-631c-486f-9b33-c5f40795d871.png?v=1769382783","url":"https:\/\/afsbio.com\/products\/tnni2-monoclonal-antibody-bt-mca4539","provider":"AFSBio Inc.","version":"1.0","type":"link"}