{"product_id":"tnnt1-polyclonal-antibody-e-ab-53126","title":"TNNT1 Polyclonal Antibody - E-AB-53126","description":"\u003cp\u003eTNNT1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-53126-60, E-AB-53126-120, E-AB-53126-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: TNNT1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: ANM; MGC104241; NEM5; Skeletal; Slow ; slow skeletal muscle; Slow skeletal muscle troponin T; sTnT; Tnnt1; TNNT1; TNT; TnTs; Troponin T; Troponin T slow skeletal muscle; Troponin T type 1 (skeletal slow); troponin T1 skeletal slow; Troponin T1; slow skeletal type\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P13805\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.66 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Fusion protein of human TNNT1\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IHC 1:25-1:50, ELISA 1:5000-1:10000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 33 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43143987953843,"sku":"E-AB-53126-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43143987986611,"sku":"E-AB-53126-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43143988019379,"sku":"E-AB-53126-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_47e58860-41c9-4c8a-bf96-595953a2c990.png?v=1710244820","url":"https:\/\/afsbio.com\/products\/tnnt1-polyclonal-antibody-e-ab-53126","provider":"AFSBio Inc.","version":"1.0","type":"link"}