{"product_id":"top1m-polyclonal-antibody-bt-ap15064","title":"TOP1M Polyclonal Antibody - BT-AP15064","description":"\u003cp\u003eTOP1M Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP15064-20, BT-AP15064-50, BT-AP15064-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: TOP1MT\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: DNA topoisomerase I, mitochondrial\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q969P6; Mouse: Q8R4U6; Rat: Q6IM78\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: DNA topoisomerase I, mitochondrial;TOP1mt;EC 5.99.1.2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 116447\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239393288371,"sku":"BT-AP15064-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239393321139,"sku":"BT-AP15064-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239393353907,"sku":"BT-AP15064-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_926846f0-0da6-4724-88ce-bc686a4cbc32.png?v=1769393912","url":"https:\/\/afsbio.com\/products\/top1m-polyclonal-antibody-bt-ap15064","provider":"AFSBio Inc.","version":"1.0","type":"link"}