{"product_id":"top2a-monoclonal-antibody-bt-mca2526","title":"TOP2A Monoclonal Antibody - BT-MCA2526","description":"\u003cp\u003eTOP2A Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2526-50, BT-MCA2526-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: TOP2A\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 6D4B2\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: TOP2A\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human TOP2A (AA: 1100-1530) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 174.4kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P11388\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: TOP2, TP2A\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 7153\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238409986227,"sku":"BT-MCA2526-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238410018995,"sku":"BT-MCA2526-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_62de1206-ce0b-4708-84c0-4385cbfec0f1.png?v=1769380226","url":"https:\/\/afsbio.com\/products\/top2a-monoclonal-antibody-bt-mca2526","provider":"AFSBio Inc.","version":"1.0","type":"link"}