{"product_id":"topo-iiibeta-1-polyclonal-antibody-bt-ap09129","title":"Topo IIIBeta-1 Polyclonal Antibody - BT-AP09129","description":"\u003cp\u003eTopo IIIBeta-1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP09129-20, BT-AP09129-50, BT-AP09129-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: TOP3B encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: TOP3B\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Topo IIIbeta-1 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 96662\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: O95985; Mouse: Q9Z321\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: TOP3B; TOP3B1; DNA topoisomerase 3-beta-1; DNA topoisomerase III beta-1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 8940; Mouse: 21976\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239954964659,"sku":"BT-AP09129-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239954997427,"sku":"BT-AP09129-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239955030195,"sku":"BT-AP09129-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_0c41fdd3-db14-4c0c-96de-b55a4c7ef652.png?v=1769401393","url":"https:\/\/afsbio.com\/products\/topo-iiibeta-1-polyclonal-antibody-bt-ap09129","provider":"AFSBio Inc.","version":"1.0","type":"link"}