{"product_id":"tph2-rabbit-polyclonal-antibody-es4690","title":"TPH2 Rabbit Polyclonal Antibody - ES4690","description":"\u003cp\u003eTPH2 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES4690-50, ES4690-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat, Monkey\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: TPH2, NTPH, Tryptophan 5-hydroxylase 2, Neuronal tryptophan hydroxylase, Tryptophan 5-monooxygenase 2\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human TPH2. AA range:4-53\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: TPH2\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: TPH2 Polyclonal Antibody detects endogenous levels of TPH2 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Brain specific,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 56kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Tryptophan metabolism, Folate biosynthesis, Metabolic pathways, Serotonergic synapse\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin\u003cbr\u003e\nCofactor: Fe(2+) ion\u003cbr\u003e\nDisease: Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM: 608516]\u003cbr\u003e\nPathway: Aromatic compound metabolism, serotonin biosynthesis, serotonin from L-tryptophan: step 1\/2\u003cbr\u003e\nSimilarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family\u003cbr\u003e\nSimilarity: Contains 1 ACT domain\u003cbr\u003e\nTissue Specificity: Brain specific\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: cytosol, neuron projection,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: TPH2\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Tryptophan 5-hydroxylase 2\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 216343\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q8CGV2\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 317675\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q8CGU9\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313482846387,"sku":"ES4690-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313482879155,"sku":"ES4690-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/tph2-rabbit-polyclonal-antibody-es4690","provider":"AFSBio Inc.","version":"1.0","type":"link"}