{"product_id":"tpor-phospho-tyr626-rabbit-polyclonal-antibody-bt-ap13143","title":"TPOR (Phospho-Tyr626) Rabbit Polyclonal Antibody - BT-AP13143","description":"\u003cp\u003eTPOR (Phospho-Tyr626) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP13143-20, BT-AP13143-50, BT-AP13143-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: In 1990 an oncogene| v-mpl| was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue| named| c-mpl| was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl| thrombopoietin| was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene| CD110| is a 635 amino acid transmembrane domain| with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic| emphasizing the important\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Immunology; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MPL\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: TPOR\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P40238; Mouse: Q08351\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: TPOR;Tyr626; Thrombopoietin receptor; TPO-R; Myeloproliferative leukemia protein; Proto-oncogene c-Mpl; CD antigen CD110\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 4352; Mouse: 17480\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239027957939,"sku":"BT-AP13143-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239027990707,"sku":"BT-AP13143-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239028023475,"sku":"BT-AP13143-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_f6426322-f39e-4868-8646-de1dc29389b4.png?v=1769388109","url":"https:\/\/afsbio.com\/products\/tpor-phospho-tyr626-rabbit-polyclonal-antibody-bt-ap13143","provider":"AFSBio Inc.","version":"1.0","type":"link"}