{"product_id":"traf2-phospho-ser11-rabbit-polyclonal-antibody-bt-ap05238","title":"TRAF2 (Phospho-Ser11) Rabbit Polyclonal Antibody - BT-AP05238","description":"\u003cp\u003eTRAF2 (Phospho-Ser11) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP05238-20, BT-AP05238-50, BT-AP05238-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with| and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors| and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8\/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs)| and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD| a TNF receptor associated apoptotic signal transducer| ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2\/c-IAP1| an apoptosis inhibitor possessing ubiquitin ligase activity| can unbiquitinate and induce the degradation of this pro\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction; Cancer; Cardiovascular; Cell biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: TRAF2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: TRAF2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q12933; Mouse: P39429\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: TRAF2;Ser11; TNF receptor-associated factor 2; EC 6.3.2.-; E3 ubiquitin-protein ligase TRAF2; Tumor necrosis factor type 2 receptor-associated protein 3\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 7186; Mouse: 22030\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239028056243,"sku":"BT-AP05238-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239028089011,"sku":"BT-AP05238-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239028121779,"sku":"BT-AP05238-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_08812e0f-122b-45b5-977f-cef70f20e9de.png?v=1769388111","url":"https:\/\/afsbio.com\/products\/traf2-phospho-ser11-rabbit-polyclonal-antibody-bt-ap05238","provider":"AFSBio Inc.","version":"1.0","type":"link"}