{"product_id":"trib2-polyclonal-antibody-bt-ap15142","title":"TRIB2 Polyclonal Antibody - BT-AP15142","description":"\u003cp\u003eTRIB2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP15142-20, BT-AP15142-50, BT-AP15142-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C\/EBPalpha (CCAAT\/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Signal transduction; Cancer; Stem cells; Cardiovascular\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: TRIB2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Tribbles homolog 2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q92519; Mouse: Q8K4K3\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Tribbles homolog 2;TRB-2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 28951\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239395745971,"sku":"BT-AP15142-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239395778739,"sku":"BT-AP15142-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239395811507,"sku":"BT-AP15142-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_81b6aa25-7a34-44b3-bfdc-1bd8f9a72cad.png?v=1769393949","url":"https:\/\/afsbio.com\/products\/trib2-polyclonal-antibody-bt-ap15142","provider":"AFSBio Inc.","version":"1.0","type":"link"}