{"product_id":"ttll12-polyclonal-antibody-e-ab-92358","title":"TTLL12 Polyclonal Antibody - E-AB-92358","description":"\u003cp\u003eTTLL12 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-92358-60, E-AB-92358-120, E-AB-92358-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: TTLL12\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: TTLL12; dJ526I14.2; tubulin tyrosine ligase like 12\u003c\/p\u003e\n\n \n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q14166\u003c\/p\u003e\n\n\u003cp\u003eBackground: Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3. Probably by controlling tubulin and\/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the DDX58\/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human TTLL12\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 74kDa\u003c\/p\u003e\n\n \n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43135939772595,"sku":"E-AB-92358-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43135939805363,"sku":"E-AB-92358-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43135939838131,"sku":"E-AB-92358-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_e303e20d-5a2c-4b10-b5d7-5ed1c8b99278.png?v=1709986842","url":"https:\/\/afsbio.com\/products\/ttll12-polyclonal-antibody-e-ab-92358","provider":"AFSBio Inc.","version":"1.0","type":"link"}