{"product_id":"tweak-p73-polyclonal-antibody-bs2454","title":"TWEAK (P73) Polyclonal Antibody-BS2454","description":"\u003cp\u003eTWEAK (P73) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS2454-50, BS2454-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: O43508\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF\u003c\/p\u003e \n\n\u003cp\u003eBackground: TWEAK is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14\/TWEAKR receptor. It is widely expressed, has high constitutive expression in heart placenta, lung, muscle, kidney, pancreas, and HUVEC. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. TWEAK can induce apoptosis via multiple pathways of cell death in a cell type specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis.\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: TWEAK (P73) polyclonal antibody detects endogenous levels of TWEAK protein.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of TWEAK (P73) polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLane 1: A549 whole cell lysate (40ug)\u003cbr\u003e\nLane 2: U-87MG whole cell lysate (40ug)\u003cbr\u003e\nLane 3: HEK293T whole cell lysate (40ug)\u003cbr\u003e\nLane 4: A2780 whole cell lysate (40ug)\u003cbr\u003e\nLane 5: SP2\/0 whole cell lysate (40ug)\u003cbr\u003e\nLane 6: C6 whole cell lysate (40ug)\u003cbr\u003e\nLane 7: PC12 whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of TWEAK (P73) pAb in paraffin-embedded human colon carcinoma tissue at 1:50.showing secreted and cell membrane staining. Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.\u003c\/p\u003e \n\n\u003cp\u003eBioworld Molecular Weight: ~ 27 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Tumor necrosis factor ligand superfamily member 12; APO3 ligand; TNF-related weak inducer of apoptosis; TWEAK; TNFSF12; APO3L; DR3LG; UNQ181\/PRO207\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 51-100 of Human TWEAK.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42953225732275,"sku":"BS2454-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42953225765043,"sku":"BS2454-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_ec516606-8a70-40d3-91ae-309b88277344.jpg?v=1705057156","url":"https:\/\/afsbio.com\/products\/tweak-p73-polyclonal-antibody-bs2454","provider":"AFSBio Inc.","version":"1.0","type":"link"}