{"product_id":"txnrd2-monoclonal-antibody-mb66540","title":"TXNRD2 Monoclonal Antibody-MB66540","description":"\u003cp\u003eTXNRD2 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB66540-50, MB66540-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q9NNW7\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB (1\/500 - 1\/1000)\u003c\/p\u003e\n\n\u003cp\u003eBackground: Thioredoxin reductases are selenoproteins that are critical for maintaining cellular redox balance and eliminating reactive oxygen species (ROS). There are three known mammalian thioredoxin reductases: TRXR1\/TXNRD1 (cytosolic), TRXR2\/TXNRD2 (mitochondrial), and TRXR3\/TXNRD3 (testis-specific). TRXR2 may function to protect against tumor necrosis factor-α (TNF-α)-mediated ROS generation. TRXR2 is critical for normal heart development and function. TRXR2 KO mice experience embryonic lethality, while mitochondrial dysfunction seen in heart-specific TRXR2 KO mice results in congestive heart failure. In humans, certain rare mutations in TRXR2 have been linked to dilated cardiomyopathy. A recent study in the EPIC-Heidelberg cohort shows that serum selenium levels, in concert with certain SNPs in TRXR2 and other selenoproteins, can influence prostate cancer risk.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was purified by immunogen affinity chromatography.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of TXNRD2 protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of TXNRD2 expression in A431 (A), U251 (B), U2OS (C), Lncap (D), Hela (E) whole cell lysates.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 56 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: KIAA1652; TRXR2; Thioredoxin reductase 2 mitochondrial; Selenoprotein Z; SelZ; TR-beta; Thioredoxin reductase TR3\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant human TXNRD2 protein fragments expressed in E.coli.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42906363363507,"sku":"MB66540-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42906363396275,"sku":"MB66540-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_7005644e-d993-4297-a865-4bc01d825802.jpg?v=1702918722","url":"https:\/\/afsbio.com\/products\/txnrd2-monoclonal-antibody-mb66540","provider":"AFSBio Inc.","version":"1.0","type":"link"}