{"product_id":"tyk-2-monoclonal-antibody-bt-mca1259","title":"Tyk 2 Monoclonal Antibody - BT-MCA1259","description":"\u003cp\u003eTyk 2 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA1259-50, BT-MCA1259-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction; Cardiovascular; Immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: TYK2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Non-receptor tyrosine-protein kinase TYK2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P29597; Mouse: Q9R117\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: TYK2; Non-receptor tyrosine-protein kinase TYK2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 7297\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238766862515,"sku":"BT-MCA1259-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238766895283,"sku":"BT-MCA1259-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_a86ceeef-c82a-497c-a0ca-3065c9db19e4.png?v=1769384522","url":"https:\/\/afsbio.com\/products\/tyk-2-monoclonal-antibody-bt-mca1259","provider":"AFSBio Inc.","version":"1.0","type":"link"}