{"product_id":"tyk-2-rabbit-pab-es3658","title":"Tyk 2 rabbit pAb - ES3658","description":"\u003cp\u003eTyk 2 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES3658-50, ES3658-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: tyrosine kinase 2 (TYK2) Homo sapiens This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: TYK2; Non-receptor tyrosine-protein kinase TYK2\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/10000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Monkey\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human TYK2. AA range:1020-1069\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 134kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 7297\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P29597\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: nucleus, cytoplasm, cytosol, cytoskeleton, membrane, extrinsic component of cytoplasmic side of plasma membrane, extracellular exosome,\u003c\/p\u003e \n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202147442867,"sku":"ES3658-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202147475635,"sku":"ES3658-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_c4856525-391a-41a7-af54-3aa6f8ca2ff0.png?v=1767123010","url":"https:\/\/afsbio.com\/products\/tyk-2-rabbit-pab-es3658","provider":"AFSBio Inc.","version":"1.0","type":"link"}