{"product_id":"tyk2-phospho-tyr1054-1055-rabbit-polyclonal-antibody-es12474","title":"Tyk2 (phospho-Tyr1054\/1055) Rabbit Polyclonal Antibody - ES12474","description":"\u003cp\u003eTyk2 (phospho-Tyr1054\/1055) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES12474-50, ES12474-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: approximately 7-10 business days, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: tyrosine kinase 2(TYK2) Homo sapiens This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008],\u003c\/p\u003e \n\n\u003cp\u003eReactivity: Human, Rat, Mouse,\u003c\/p\u003e \n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized phosho peptide around human Tyk2 (Tyr1054 and 1055)\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: Tyk2,\u003c\/p\u003e \n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of Human Tyk2 (phospho-Tyr1054 or 1055)\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:1000-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e \n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 134kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Necroptosis, Osteoclast differentiation, NOD-like receptor signaling pathway, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Hepatitis C, Hepatitis B, Measles, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease - COVID-19\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Disease: Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also called autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. The syndrome consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE. Domain: The FERM domain mediates interaction with JAKMIP1. Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha\/beta receptor alpha chain. online information:TYK2 mutation db, Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. Similarity: Contains 1 FERM domain. Similarity: Contains 1 protein kinase domain. Similarity: Conta\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: nucleus, cytoplasm, cytosol, cytoskeleton, membrane, extrinsic component of cytoplasmic side of plasma membrane, extracellular exosome,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: TYK2\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Tyk2, Tyr1054\/1055\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 7297\u003c\/p\u003e\n\n\u003cp\u003eHuman SwissProt Number: P29597\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q9R117\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":45825497792691,"sku":"ES12474-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45825497825459,"sku":"ES12474-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk-biotechnology-logo-product.jpg?v=1786476023","url":"https:\/\/afsbio.com\/products\/tyk2-phospho-tyr1054-1055-rabbit-polyclonal-antibody-es12474","provider":"AFSBio Inc.","version":"1.0","type":"link"}