{"product_id":"tyk2-polyclonal-antibody-bs91391","title":"Tyk2 Polyclonal Antibody-BS91391","description":"\u003cp\u003eTyk2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS91391-50, BS91391-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P29597\u003c\/p\u003e \n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:500-1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: TYK2 belongs to the family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions occurring downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, recruit STAT transcription factors to the cytokine receptor where TYK2 is associated. TYK2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus, and bind to cis elements upstream of target gene promoters to regulating transcription. The canonical JAK-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Cytokine induced pro-inflammatory responses are attractive targets for anti-inflammatory therapies, specifically at the level of Jak-STAT signaling.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Protein affinity purified.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of Tyk2 pAb at 1:500 dilution\u003cbr\u003e\n Lane 1:MCF-7 whole cell lysate (40ug)\u003cbr\u003e\n Lane 2:The kidney tissue lysate of Rat (40ug)\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 150 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Tyk2 polyclonal antibody detects endogenous levels of Tyk2 protein.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: TYK2, JTK 1, JTK1, Non receptor tyrosine protein kinase 2, Non receptor tyrosine protein kinase TYK2, Non-receptor tyrosine-protein kinase TYK2, OTTHUMP00000232745, OTTHUMP00000232746, OTTHUMP00000232748, Protein Tyrosine Kinase 2, TYK 2, Tyk2, TYK2, Tyrosine kinase 2,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Recombinant protein within human TYK2 aa 400-600.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42939196997811,"sku":"BS91391-50","price":415.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42939197030579,"sku":"BS91391-100","price":640.78,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_e1f0175f-9ffe-4190-adc0-aac9b4f71b10.jpg?v=1704544910","url":"https:\/\/afsbio.com\/products\/tyk2-polyclonal-antibody-bs91391","provider":"AFSBio Inc.","version":"1.0","type":"link"}