{"product_id":"tyro3-monoclonal-antibody-bt-mca2672","title":"TYRO3 Monoclonal Antibody - BT-MCA2672","description":"\u003cp\u003eTYRO3 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2672-50, BT-MCA2672-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: TYRO3: Tyrosine-protein kinase, also known as BYK, Brt, Dtk, Sky. Entrez Protein: NP_006284. It belongs to the Tyr protein kinase family (AXL\/UFO subfamily). The UFO family of receptor tyrosine kinases is comprised of subfamily members Rse(also referred to as Tyro3 or Sky) and UFO (also called Tyro7 or Axl). Two distinct isoforms of Rse, designated Brt and Etk-2, have been described. Brt differs from Rse at its C-terminus, but more importantly lacks the N-terminal 31 amino acid signal peptide sequence present in Rse, which is replaced by a 27 amino acid Brt-specific sequence. It has been suggested that as a result of this alternative splicing event, Brt resides in the cytoplasm, unlike Rse which is expressed on the cell surface. Ekt-2 also lacks an N-terminal signal peptide which is substituted with a 45 amino acid Ekt-2-specific sequence. Protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction, Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: TYRO3\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 10E11\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: TYRO3\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant extracellular fragment of human TYRO3 fused with hIgGFc tag expressed in HEK293 cell line.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 96.9kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Q06418\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: BYK, Brt, Dtk, RSE, Sky, Tif\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 7301\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238427844787,"sku":"BT-MCA2672-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238427877555,"sku":"BT-MCA2672-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_926f50d4-7422-4108-b0d6-9831743e1b4d.png?v=1769380643","url":"https:\/\/afsbio.com\/products\/tyro3-monoclonal-antibody-bt-mca2672","provider":"AFSBio Inc.","version":"1.0","type":"link"}