{"product_id":"ub2d1-polyclonal-antibody-bt-ap15277","title":"UB2D1 Polyclonal Antibody - BT-AP15277","description":"\u003cp\u003eUB2D1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP15277-20, BT-AP15277-50, BT-AP15277-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling; Cell biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: UBE2D1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Ubiquitin-conjugating enzyme E2 D1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P51668; Mouse: P61080; Rat: D3ZDK2\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Ubiquitin-conjugating enzyme E2 D1;EC 6.3.2.19;Stimulator of Fe transport;SFT;UBC4\/5 homolog;UbcH5;Ubiquitin carrier protein D1;Ubiquitin-conjugating enzyme E2;17KB 1;Ubiquitin-conjuga\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 7321\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239400759475,"sku":"BT-AP15277-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239400792243,"sku":"BT-AP15277-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239400825011,"sku":"BT-AP15277-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_ba4b2d1a-fc6a-4498-84ea-83020883359c.png?v=1769394014","url":"https:\/\/afsbio.com\/products\/ub2d1-polyclonal-antibody-bt-ap15277","provider":"AFSBio Inc.","version":"1.0","type":"link"}