{"product_id":"ube3a-polyclonal-antibody-e-ab-62254","title":"UBE3A Polyclonal Antibody - E-AB-62254","description":"\u003cp\u003eUBE3A Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-62254-60, E-AB-62254-120, E-AB-62254-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: UBE3A\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: UBE3A; ANCR; AS; E6-AP; EPVE6AP; HPVE6A\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology, Epigenetics and Nuclear Signaling, Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q05086\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human UBE3A (NP_570853.1).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB \t1:500-1:2000   IHC \t1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 97kDa\/100kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 110kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146233872563,"sku":"E-AB-62254-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146233905331,"sku":"E-AB-62254-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146233938099,"sku":"E-AB-62254-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_80554174-c3cd-4395-abae-b8f696f5baa0.png?v=1710292108","url":"https:\/\/afsbio.com\/products\/ube3a-polyclonal-antibody-e-ab-62254","provider":"AFSBio Inc.","version":"1.0","type":"link"}