{"product_id":"unc13b-polyclonal-antibody-e-ab-52441","title":"UNC13B Polyclonal Antibody - E-AB-52441","description":"\u003cp\u003eUNC13B Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-52441-60, E-AB-52441-120, E-AB-52441-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: UNC13B\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: hmunc13; MGC133279; MGC133280; munc13; Munc13-2; Protein unc-13 homolog B; UN13B; unc-13 homolog B (C. elegans); UNC13; Unc13b; Unc13h2\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Neuroscience, Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: O14795\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1.5 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Fusion protein of human UNC13B\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:50-1:300, ELISA 1:5000-1:10000\u003c\/p\u003e\n\n \n\n \n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43133464576179,"sku":"E-AB-52441-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43133464608947,"sku":"E-AB-52441-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43133464641715,"sku":"E-AB-52441-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_ba88f6d4-08c7-4ab0-9420-d51d833e1da0.png?v=1709899369","url":"https:\/\/afsbio.com\/products\/unc13b-polyclonal-antibody-e-ab-52441","provider":"AFSBio Inc.","version":"1.0","type":"link"}