{"product_id":"usp2-polyclonal-antibody-e-ab-10878","title":"USP2 Polyclonal Antibody - E-AB-10878","description":"\u003cp\u003eUSP2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-10878-60, E-AB-10878-120, E-AB-10878-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: USP2\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: 41 kDa ubiquitin specific protease; 41 kDa ubiquitin-specific protease; Deubiquitinating enzyme 2; Ubiquitin carboxyl terminal hydrolase 2; Ubiquitin carboxyl-terminal hydrolase 2; ubiquitin specific peptidase 2; Ubiquitin specific processing protease 2; Ubiquitin specific protease 12; Ubiquitin specific protease 9; Ubiquitin specific protease; 41kD; Ubiquitin thioesterase 2; Ubiquitin thiolesterase 2; Ubiquitin-specific-processing protease 2; Ubiquitin-specific-processing protease testis; UBP-t; UBP2; UBP41; USP2; USP9\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology, Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: O75604\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4\/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1\/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.3 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein of human USP2\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"200μL","offer_id":43124061405363,"sku":"E-AB-10878-200","price":558.6,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43124061438131,"sku":"E-AB-10878-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"60μL","offer_id":43124061470899,"sku":"E-AB-10878-60","price":200.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_5ad29c3a-7f6e-4643-b914-ed5acac4bc2c.png?v=1709723199","url":"https:\/\/afsbio.com\/products\/usp2-polyclonal-antibody-e-ab-10878","provider":"AFSBio Inc.","version":"1.0","type":"link"}