{"product_id":"vav1-monoclonal-antibody-bt-mca2621","title":"VAV1 Monoclonal Antibody - BT-MCA2621","description":"\u003cp\u003eVAV1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2621-50, BT-MCA2621-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK\/SAPK signaling cascade, leading to increased levels of viral transcription and replication.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: VAV1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 2E11\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: VAV1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 98.3kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P15498\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: VAV\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 7409\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238579495091,"sku":"BT-MCA2621-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238579527859,"sku":"BT-MCA2621-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_134e507b-b6ea-4480-91b9-cc989ec259ce.png?v=1769382769","url":"https:\/\/afsbio.com\/products\/vav1-monoclonal-antibody-bt-mca2621","provider":"AFSBio Inc.","version":"1.0","type":"link"}