{"product_id":"ve-cadherin-phospho-y731-polyclonal-antibody-bs4242","title":"VE-Cadherin (phospho-Y731) Polyclonal Antibody-BS4242","description":"\u003cp\u003eVE-Cadherin (phospho-Y731) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS4242-50, BS4242-100\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P33151\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eVE-Cadherin (phospho-Y731) Polyclonal Antibody-BS4242\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003cbr\u003e\nIHC: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: The cadherins are a family of Ca 2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy-terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including β-catenin, to regulate cadherin function. VE-cadherin (for vascular endothelial cadherin, also designated cadherin-5) is localized at intercellular junctions of endothelial cells, where it is thought to play a role in the cohesion and organization of intercellular junctions.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: p-VE-Cadherin (Y731) polyclonal antibody detects endogenous levels of VE-Cadherin protein only when phosphorylated at Tyr731\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 130 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of p-VE-Cadherin (Y731) polyclonal antibody at 1:500 dilution\u003cbr\u003e\n Lane 1: Hela cell lysate treated with EGF (0.1ng\/ml,30mins) \u003cbr\u003e\n Lane 2: H9C2 cell lysate treated with EGF (0.1ng\/ml,30mins), Immunohistochemistry (IHC) analyzes of p-VE-Cadherin (Y731) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Cadherin-5; 7B4 antigen; Vascular endothelial cadherin; VE-cadherin; CD144; CDH5; Cadherin 5\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic phosphopeptide derived from human VE-Cadherin around the phosphorylation site of Tyrosine 731.\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylation\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42957297320115,"sku":"BS4242-50","price":276.71,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42957297352883,"sku":"BS4242-100","price":490.83,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_681e714b-002a-4c92-8051-682dfa6203c6.jpg?v=1705144520","url":"https:\/\/afsbio.com\/products\/ve-cadherin-phospho-y731-polyclonal-antibody-bs4242","provider":"AFSBio Inc.","version":"1.0","type":"link"}