{"product_id":"vegf-rabbit-rabbit-pab-es20599","title":"VEGF Rabbit rabbit pAb - ES20599","description":"\u003cp\u003eVEGF Rabbit rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES20599-50, ES20599-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene is a member of the PDGF\/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation fro\u003c\/p\u003e\n\n\u003cp\u003eAlternate Name: VEGFA\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: IF; WB; IHC; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: IF: 1:50-200 WB 1:500-2000, IHC 1:50-300 IHC 1:50-300\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Rat; Mouse\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant Protein of VEGF of VEGFA\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 21kD (monomer), 42kD (dimer)\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 7422\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P15692\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Secreted. VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a significant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202429771955,"sku":"ES20599-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202429804723,"sku":"ES20599-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_e6a1a94b-6bfc-4e33-a5d1-cc653d13a7d8.png?v=1767129034","url":"https:\/\/afsbio.com\/products\/vegf-rabbit-rabbit-pab-es20599","provider":"AFSBio Inc.","version":"1.0","type":"link"}