{"product_id":"vhl-polyclonal-antibody-bt-ap15472","title":"VHL Polyclonal Antibody - BT-AP15472","description":"\u003cp\u003eVHL Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP15472-20, BT-AP15472-50, BT-AP15472-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G\/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Metabolism; Cancer; Cell biology; Epigenetics and nuclear signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: VHL\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-p, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Von Hippel-Lindau disease tumor suppressor\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P40337; Mouse: P40338\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Von Hippel-Lindau disease tumor suppressor;Protein G7;pVHL; Von Hippel-Lindau disease tumor suppressor; Protein G7; pVHL\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 7428; Mouse: 22346\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239410426035,"sku":"BT-AP15472-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239410458803,"sku":"BT-AP15472-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239410491571,"sku":"BT-AP15472-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_5a51cfb5-59e7-49dc-92f5-43aec0be72dd.png?v=1769394124","url":"https:\/\/afsbio.com\/products\/vhl-polyclonal-antibody-bt-ap15472","provider":"AFSBio Inc.","version":"1.0","type":"link"}