{"product_id":"vhl-polyclonal-antibody-ra36058","title":"VHL Polyclonal Antibody - RA36058","description":"\u003cp\u003eVHL Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA36058-50, RA36058-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: von Hippel-Lindau tumor suppressor (VHL) Homo sapiens Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G\/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: IHC-p 1:50-200, ELISA 1:10000-20000\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: Von Hippel-Lindau disease tumor suppressor (Protein G7;pVHL)\u003c\/p\u003e \n\n\u003cp\u003eApplications: IHC-p; IF (paraffin section) ; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Rat; Mouse\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 7428\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P40337\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45120373031091,"sku":"RA36058-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45120373063859,"sku":"RA36058-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_84a28668-f75a-4e8a-bae6-b3438c216276.png?v=1773357927","url":"https:\/\/afsbio.com\/products\/vhl-polyclonal-antibody-ra36058","provider":"AFSBio Inc.","version":"1.0","type":"link"}