{"product_id":"vmat2-rabbit-polyclonal-antibody-es11255","title":"VMAT2 Rabbit Polyclonal Antibody - ES11255","description":"\u003cp\u003eVMAT2 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES11255-50, ES11255-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: approximately 7-10 business days, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011],\u003c\/p\u003e \n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human protein . at AA range: 1-80\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: VMAT2,\u003c\/p\u003e \n\n\u003cp\u003eSpecificity: VMAT2 Polyclonal Antibody detects endogenous levels of protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e \n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Brain, Platelet, Substantia nigra, Testis,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 56kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Synaptic vesicle cycle, Serotonergic synapse, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Alcoholism\u003c\/p\u003e\n\n\u003cp\u003eFunction: Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis. online information:Vesicular monoamine transporter entry, Similarity: Belongs to the major facilitator superfamily. Vesicular transporter family.\u003c\/p\u003e \n\n\u003cp\u003eSubcellular Location: Cytoplasmic vesicle membrane, Multi-pass membrane protein.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: SLC18A2, SVMT, VMAT2\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Synaptic vesicular amine transporter, Monoamine transporter, Solute carrier family 18 member 2, Vesicular amine transporter 2, VAT2\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 6571\u003c\/p\u003e\n\n\u003cp\u003eHuman SwissProt Number: Q05940\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q8BRU6\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q01827\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":45825499594931,"sku":"ES11255-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45825499627699,"sku":"ES11255-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk-biotechnology-logo-product.jpg?v=1786476023","url":"https:\/\/afsbio.com\/products\/vmat2-rabbit-polyclonal-antibody-es11255","provider":"AFSBio Inc.","version":"1.0","type":"link"}