Whole Genome Bisulfite Sequencing, (WGBS)

Whole Genome Bisulfite Sequencing, (WGBS)

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WGBS detects DNA methylation of single cytosine bases by treating DNA with bisulfite prior to sequencing. It functions at the single-base level to identify and analyze the methylation of each C-base to construct a genome wide methylation map. WGBS is the gold standard for methylation analysis. 

DNA methylation helps regulate genes: it maintains chromosome structure; X chromosome inactivation, genetic imprinting, embryonic development and regular cell body processes.