{"product_id":"wt1-polyclonal-antibody-bt-ap15559","title":"WT1 Polyclonal Antibody - BT-AP15559","description":"\u003cp\u003eWT1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP15559-20, BT-AP15559-50, BT-AP15559-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline\/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling; Developmental biology; Cancer; Tags and cell markers\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: WT1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Wilms tumor protein\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P19544; Mouse: P22561; Rat: P49952\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Wilms tumor protein;WT33\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 7490\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239419273395,"sku":"BT-AP15559-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239419306163,"sku":"BT-AP15559-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239419338931,"sku":"BT-AP15559-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_43481e0e-f338-4bb4-9889-aa53e6810a1a.png?v=1769394189","url":"https:\/\/afsbio.com\/products\/wt1-polyclonal-antibody-bt-ap15559","provider":"AFSBio Inc.","version":"1.0","type":"link"}